Raymond was born Raymond Guion on August 13, 1908 in New York City. He attended the Professional Children's School while appearing in productions like Rip Van Winkle and Mrs. Wiggs of the Cabbage Patch. His Broadway debut, at age 17, was in The Cradle Snatchers which ran two years. (The cast included Mary Boland, Edna May Oliver, and a young Humphrey Bogart.)
His screen debut was in Personal Maid (1931). Another early appearance was in the multi-director If I Had a Million with W. C. Fields and Charles Laughton. With his blond good looks, classic profile, and youthful exuberance — plus a name change to the more pronounceable "Gene Raymond" — he scored in films like the classic Zoo in Budapest with Loretta Young, and a series of light RKO musicals, mostly with Ann Sothern. He wrote a number of songs, including the popular "Will You?" which he sang to Sothern in Smartest Girl In Town (1936). His wife, Jeanette MacDonald, sang several of his more classical pieces in her concerts and recorded one entitled "Let Me Always Sing".
His most notable films, mostly as a second lead actor, include Red Dust (1932) with Jean Harlow, Zoo in Budapest (1933) with Loretta Young, Ex-Lady (1933) with Bette Davis,Flying Down to Rio (1933) with Dolores del Río, Fred Astaire and Ginger Rogers, I Am Suzanne (1934) with Lilian Harvey, Sadie McKee (1934) with Joan Crawford, Alfred Hitchcock's Mr. and Mrs. Smith (1941) with Carole Lombard and Robert Montgomery, and The Locket (1946) with Laraine Day, Brian Aherne, and Robert Mitchum. MacDonald and Raymond made one film together, Smilin' Through, which came out as the U.S. was on the verge of entering the World War II. After the war, Raymond both directed and starred in the suspense drama Million Dollar Weekend (1948).
Following the beginning of war in Europe in 1939, Raymond felt certain the U.S. would eventually enter the war. He trained as a pilot for that eventuality, and after the attack on Pearl Harbor in 1941, he was commissioned a lieutenant in the Army Air Forces. He served as an observer aboard B-17 anti-submarine flights along the Atlantic coast before attending intelligence school and shipping out to England in July 1942. He served with the 97th Bomb Group before taking over as assistant operations officer in the 8th Bomber Command. He was transferred back to the U.S. in 1943 and piloted a variety of aircraft, both bombers and fighters, in stateside duties. He remained in the United States Air Force Reserve following the war, retiring in 1968 as a colonel.
On May 2, 1998, Raymond died of pneumonia in Los Angeles, California.
For his contribution to the motion picture and television industry, Gene Raymond has two stars on the Hollywood Walk of Fame located at 7003 Hollywood Boulevard and 1704 Vine Street.