Clyde is best known for his characters in two long-running television series: as the farmer Cully Wilson in CBS's Lassie and as the neighbor, George MacMichael, on ABC's The Real McCoys. Coincidentally, he appeared in twenty-nine episodes in both of these series.

In 1912, Clyde first came to the United States on tour in a company performing a play called The Concealed Bed. Years later, at the invitation of his close friend James Finlayson, he returned to the United States in 1920 to join producer Mack Sennett's roster of comedians.
Clyde's mastery of makeup allowed him tremendous versatility; he could play everything from grubby young guttersnipes to old crackpot scientists. He hit upon an "old man" characterization in his short comedies, which were immediately successful. Adopting a gray wig and mustache, he used this makeup for the rest of his short-subject career, and the character was so durable that he literally grew into it. He starred in short comedies longer than any other actor (32 years, 1924-56).
He remained with Mack Sennett and made a successful transition to sound films. In 1932, when the Sennett studio was facing financial problems, Sennett cut Clyde's salary. Clyde objected and Sennett put the "old man" costume on character actor Irving Bacon. Audiences reacted adversely, and Sennett abandoned the character. Educational Pictures, Sennett's distributor, took over the Andy Clyde series, which continued for two more years.
Columbia Pictures launched its short subject department in 1934 and Andy Clyde was one of the first comedy stars signed by producer Jules White. Unlike many of the Columbia short-subject comedians who indulged in broad facial and physical gestures, Clyde was subtler and more economical: his comic timing was so good that he could merely lift an eyebrow, shudder slightly, or mutter "My, my, my" for humorous effect. His work for Columbia was so prolific that, from the mid-1940s, the studio was able to produce lower-budgeted remakes, editing older scenes into the new ones.You Were Never Uglier (1944), for example, was remade with the same principals in 1953 as Hooked and Rooked. Clyde was such an audience favorite that he continued to star in Columbia shorts through 1956. He outlasted every comedian on the Columbia payroll except The Three Stooges.
Clyde also kept busy as a character actor in feature films; for example, he played a sad provincial postman in the Katharine Hepburn film The Little Ministerand Charles Coburn's drinking buddy in The Green Years. In the 1940s, he gravitated toward outdoor and western adventures. Clyde is well remembered for his roles as a comic sidekick, usually teaming with William Boyd in the Hopalong Cassidy series, as "California Carlson", or with Whip Wilson in Monogram Pictures' low-budget western movies. Clyde also worked on the Hopalong Cassidy "record readers" issued by Capitol Records in the 1950s.
Clyde's last theatrical film was released in 1956, after which he worked mostly in television, having appeared on Rod Cameron's syndicated series City Detective. On The Pepsi-Cola Playhouse and Studio 57 in 1954 and 1955, respectively, he portrayed Tom Harper in the episode "Santa's Old Suit," with co-star Jane Darwell. Clyde guest starred in several other early series too, including The People's Choice, Soldiers of Fortune, My Little Margie, The Bob Cummings Show, and Lock Up.
He appeared in two children's programs: as Colonel Jack in four episodes of Circus Boy and as Homer Tubbs in four segments of ABC's western series, The Adventures of Rin Tin Tin.
In 1959, Clyde played Captain Gibbs in two segments of the ABC/Warner Brothers western series, Colt .45. As "Scatterbrain Gibbs", he appeared with Tol Avery as Barnes in "Queen of Dixie"; in the story line, series character Christopher Colt (Wayde Preston) is aboard a Mississippi River gambling boat and encounters a ring of counterfeiters. Clyde subsequently played "Captain Gibbs" in the episode "Yellow Terror", with Brad Dexter in the role of John Barker.
That same year, Clyde portrayed "Millionaire Andrew C. Cooley" in CBS's fantasy drama, The Millionaire.
Clyde and Denver Pyle were cast in the 1960 episode "The Man Who Wanted Everything" of the ABC western drama, The Man from Blackhawk, starring Robert Rockwell as a roving insurance investigator.
From 1960 to 1962, Clyde was cast as the farmer Pa McBeam in five episodes of NBC's western series, The Tall Man, starring Barry Sullivan and Clu Gulager. Judy Nugent plays McBean's daughter, June. In "The Reluctant Bridegroom" (February 18, 1961), Ellen Corby is featured as Hannah Blossom, a potential mail order bride, for Pa McBeam. Through a fraudulent letter written by the McBeam daughters, Hannah is lured to Lincoln, New Mexico, the setting of the series, to seek out the potential husband.In "Substitute Sheriff" (January 6, 1962), the McBeam daughters enlist their father as an acting sheriff in a scheme to thwart the seizure of their property for right-of-way by the railroad. Bob Hastings appears in this episode as J. S. Chase.
In 1962-1963, Clyde portrayed Dr. Parkinson in three episodes of NBC's medical drama, Dr. Kildare, starring Richard Chamberlain.
Clyde was featured several times on Rory Calhoun's CBS western series, The Texan, including the part of Wild Jack Hastings in "The Troubled Town" and in additional segments as the character Andy Miles.
Clyde further guest starred in such westerns as Wagon Train, Tales of the Texas Rangers, The Restless Gun, Jefferson Drum, Buckskin, Fury, Shotgun Slade, The Man from Blackhawk, andThe Life and Legend of Wyatt Earp (as Billy Buckett).
On Lassie, Clyde played the eccentric farmer and nature lover, Cully Wilson, the friend to Timmy Martin, portrayed by child actor Jon Provost, in much the same fashion as Burt Mustin was cast as Gus the Fireman for Jerry Mathers in Leave It to Beaver. In The Real McCoys, Clyde performed as the foil for another veteran character actor, Walter Brennan. Clyde played friendly, usually sincere neighbor George MacMichael to Brennan's devious "Grandpa Amos McCoy." Madge Blake played Flora, the sister of George McMichael with something of a romantic interest in Amos McCoy. Later, Clyde was cast as Skippy Draper in one episode of another Brennan ABC series, The Tycoon.
In 1961, on CBS's The Andy Griffith Show, Clyde played Frank Myers, an eccentric old man whom the town tries to evict in the episode "Mayberry Goes Bankrupt." Clyde portrayed Poney Thompson in "Snakebite" in 1958 and Henry Squires in "Durham Bull" in 1962 on CBS's long-running Gunsmoke. Clyde appeared as Grandpa Jim Anderson in five episodes of the 1964-1965 ABC military comedy, No Time for Sergeants, starring Sammy Jackson. The series was inspired by an earlier Andy Griffith film of the same name.
On September 23, 1932, in Ontario in San Bernardino Couty, California, Clyde married Elsie Maud Tarron, once a part of the Sennett Bathing Beauties. Jules White recalled that Clyde became a father in middle age, and was devastated when his nine-year-old son, John Allan Clyde, died.
Clyde continued to perform on television until his death. He is interred at Forest Lawn Memorial Park in Glendale, California. He has a star on the Hollywood Walk of Fame.

Source: Wikipedia