This is the life of baseball's beloved Lou Gehrig and is a radio version of the 1942 motion picture directed by Sam Wood. Gary Cooper reprises his original screen role as Lou Gehrig known affectionately as the Iron Horse. Lou Gehrig was recognised as another Babe Ruth and signed up by the New York Yankees whom he played for for fourteen years. This story is told by Sam Blake who introduced rookie Lou to the manager of the Yankees and got him signed up. Sam Blake became his best friend and best man at his wedding to Eleanor. The story recounts Gehrig's life, success and unfortunate demise to ALS a neurological disease, which ended his baseball career after two thousand and thirty consecutive games and fourteen years a legend in the history of baseball. The fans who loved him paid tribute with a Lou Gehrig day at the Yankee Stadium. Gehrig gave his famous Luckiest Man speech. 

Lou Gehrig died on 2nd June 1941,  just three weeks before his 38th birthday. In the USA the disease ALS is named after Lou Gehrig.

At the end of the show Cecille B DeMille pays tribute to the Screen Director Sam Wood.